Reaction Details
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Substance-K receptor
Ligand
BDBM82262
Substrate
n/a
Ki
2±n/a nM
Comments
PDSP_2000
Citation
Aharony, D; Buckner, CK; Ellis, JL; Ghanekar, SV; Graham, A; Kays, JS; Little, J; Meeker, S; Miller, SC; Undem, BJ Pharmacological characterization of a new class of nonpeptide neurokinin A antagonists that demonstrate species selectivity. J Pharmacol Exp Ther 274:1216-21 (1995) [PubMed] More Info.:
Target
Name:
Substance-K receptor
Synonyms:
NK2R_MESAU | Neurokinin 2 receptor | Neurokinin NK2 | TAC2R | TACR2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43436.75
Organism:
HAMSTER
Description:
P51144
Residue:
384
Sequence:
MGGRAIVTDTNIFSGLESNTTGVTAFSMPAWQLALWATAYLGLVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPITKATIAGIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKMLLLYHLVVFVLVYFLPLVVMFVAYSVIGLTLWKRAVPRHQAHGANLRHLHAKKKFVKAMVLVVLTFAICWLPYHLYFILGSFQKDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDRLELTRTPSLSRRVNRCHTKETLFMTADMTHSEATNGQVGSPQDVEPAAP
Inhibitor
Name:
BDBM82262
Synonyms:
ZM253,270
Type:
n/a
Emp. Form.:
C22H26ClN7O3
Mol. Mass.:
471.94
SMILES:
CC(C)N1Cc2c(nc(nc2Nc2ccc(Cl)cc2)N2CCN(CC2)C(=O)C(C)N=O)C1=O
Structure:
