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Target
Envelope glycoprotein gp160
Ligand
BDBM272526
Substrate
n/a
Meas. Tech.
Infectivity Assay
EC50
22.0±n/a nM
Citation
 Connolly, TP; Eastman, KJ; Naidu, BN; Peese, K Imidazo[1,2-A]pyridine derivatives for use as inhibitors of human immunodeficiency virus replication US Patent  US10065953 Publication Date 9/4/2018 
Target
Name:
Envelope glycoprotein gp160
Synonyms:
ENV_HV1BR | Env polyprotein | env
Type:
PROTEIN
Mol. Mass.:
97512.49
Organism:
Human immunodeficiency virus type 1 (isolate BRU/LAI group M subtypeB) (HIV-1)
Description:
ChEMBL_536779
Residue:
861
Sequence:
MRVKEKYQHLWRWGWKWGTMLLGILMICSATEKLWVTVYYGVPVWKEATTTLFCASDAKAYDTEVHNVWATHACVPTDPNPQEVVLVNVTENFNMWKNDMVEQMHEDIISLWDQSLKPCVKLTPLCVSLKCTDLGNATNTNSSNTNSSSGEMMMEKGEIKNCSFNISTSIRGKVQKEYAFFYKLDIIPIDNDTTSYTLTSCNTSVITQACPKVSFEPIPIHYCAPAGFAILKCNNKTFNGTGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSANFTDNAKTIIVQLNQSVEINCTRPNNNTRKSIRIQRGPGRAFVTIGKIGNMRQAHCNISRAKWNATLKQIASKLREQFGNNKTIIFKQSSGGDPEIVTHSFNCGGEFFYCNSTQLFNSTWFNSTWSTEGSNNTEGSDTITLPCRIKQFINMWQEVGKAMYAPPISGQIRCSSNITGLLLTRDGGNNNNGSEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTKAKRRVVQREKRAVGIGALFLGFLGAAGSTMGARSMTLTVQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQQLLGIWGCSGKLICTTAVPWNASWSNKSLEQIWNNMTWMEWDREINNYTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWFNITNWLWYIKIFIMIVGGLVGLRIVFAVLSIVNRVRQGYSPLSFQTHLPTPRGPDRPEGIEEEGGERDRDRSIRLVNGSLALIWDDLRSLCLFSYHRLRDLLLIVTRIVELLGRRGWEALKYWWNLLQYWSQELKNSAVSLLNATAIAVAEGTDRVIEVVQGACRAIRHIPRRIRQGLERILL
  
Inhibitor
Name:
BDBM272526
Synonyms:
US10065953, Example 8
Type:
Small organic molecule
Emp. Form.:
C37H43N5O3
Mol. Mass.:
605.769
SMILES:
Cc1cc2nc(cn2c(N2CCC(C)(C)CC2)c1[C@H](OC(C)(C)C)C(O)=O)-c1cccc(c1)-c1cnn(Cc2ccccc2)c1 |r|
Structure:
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