Reaction Details Report a problem with these data
Target
Virion infectivity factor
Ligand
BDBM272474
Substrate
n/a
Meas. Tech.
HIV Integrase Inhibitory Assay
Temperature
298.15±n/a K
IC50
6.50±n/a nM
Comments
extracted
Citation
 Miyazaki, S; Bessho, Y; Adachi, K; Kawashita, S; Isoshima, H; Oshita, K; Fukuda, S Substituted thiazoles as HIV integrase inhibitors US Patent  US10065950 Publication Date 9/4/2018 
Target
Name:
Virion infectivity factor
Synonyms:
HIV integrase | SOR | VIF_HV1N5 | Virion infectivity factor | inhibitory activity | vif
Type:
Enzyme Catalytic Domain
Mol. Mass.:
22719.51
Organism:
Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)
Description:
P12504
Residue:
192
Sequence:
MENRWQVMIVWQVDRMRINTWKRLVKHHMYISRKAKDWFYRHHYESTNPKISSEVHIPLGDAKLVITTYWGLHTGERDWHLGQGVSIEWRKKRYSTQVDPDLADQLIHLHYFDCFSESAIRNTILGRIVSPRCEYQAGHNKVGSLQYLALAALIKPKQIKPPLPSVRKLTEDRWNKPQKTKGHRGSHTMNGH
  
Inhibitor
Name:
BDBM272474
Synonyms:
US10065950, Example 318
Type:
Small organic molecule
Emp. Form.:
C22H23FN4O4S
Mol. Mass.:
458.506
SMILES:
CCN1C(=O)c2c(O)c(=O)c(cn2C[C@]1(C)COC)-c1nnc(Cc2ccc(F)cc2)s1 |r|
Structure:
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