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Target
Histamine H1 receptor
Ligand
BDBM50292411
Substrate
n/a
Ki
0.31±n/a nM
Comments
PDSP_1917
Citation
 Moguilevsky, N; Varsalona, F; Noyer, M; Gillard, M; Guillaume, JP; Garcia, L; Szpirer, C; Szpirer, J; Bollen, A Stable expression of human H1-histamine-receptor cDNA in Chinese hamster ovary cells. Pharmacological characterisation of the protein, tissue distribution of messenger RNA and chromosomal localisation of the gene. Eur J Biochem 224:489-95 (1994) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
HISTAMINE H1 | HRH1 | HRH1_CAVPO
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55641.53
Organism:
Cavia porcellus (domestic guinea pig)
Description:
Guinea pig cerebellum was used in binding assay.
Residue:
488
Sequence:
MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP
  
Inhibitor
Name:
BDBM50292411
Synonyms:
(E)-2-(3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl)pyridine | 1-((E)-3-Pyridin-2-yl-3-p-tolyl-allyl)-pyrrolidinium | 2-((E)-3-Pyrrolidin-1-yl-1-p-tolyl-propenyl)-pyridine | 2-(3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl)pyridine | 2-(3-Pyrrolidin-1-yl-1-p-tolyl-propenyl)-pyridine | Actahist | Actidil | Actifed | Allerfed | CHEMBL855 | Corphed | Histafed | Myfed | Myidyl | TRIPROLIDINE | Triacin-C | Trilitron | Triphed | Triprolidin
Type:
Small organic molecule
Emp. Form.:
C19H22N2
Mol. Mass.:
278.3914
SMILES:
Cc1ccc(cc1)C(=C/CN1CCCC1)\c1ccccn1
Structure:
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