Reaction Details Report a problem with these data
Target
Hepatocyte growth factor receptor [1038-1346]
Ligand
BDBM106294
Substrate
n/a
Meas. Tech.
c-Met In Vitro Kinase Assay
Temperature
303.15±n/a K
IC50
247±n/a nM
Comments
extracted
Citation
 Zhong, B; Shih, C; Yuan, H; Zhou, F Highly selective c-Met inhibitors as anticancer agents US Patent  US9695175 Publication Date 7/4/2017 
Target
Name:
Hepatocyte growth factor receptor [1038-1346]
Synonyms:
Hepatocyte growth factor receptor (MET) | MET | MET_HUMAN
Type:
n/a
Mol. Mass.:
34804.00
Organism:
Homo sapiens (Human)
Description:
c-Met kinase (1038-1346 aa)
Residue:
309
Sequence:
GDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIG
  
Inhibitor
Name:
BDBM106294
Synonyms:
US9695175, 16
Type:
Small organic molecule
Emp. Form.:
C21H17F3N8O2
Mol. Mass.:
470.4073
SMILES:
Cn1cc2c(F)c(ccc2n1)C(F)(F)c1nnc2ccc(nn12)-c1cnn(CC2COCO2)c1
Structure:
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