Reaction Details Report a problem with these data
Target
Hepatocyte growth factor receptor [1038-1346]
Ligand
BDBM107317
Substrate
n/a
Meas. Tech.
c-Met In Vitro Kinase Assay
Temperature
303.15±n/a K
IC50
38±n/a nM
Comments
extracted
Citation
 Zhong, B; Shih, C; Yuan, H; Zhou, F Highly selective c-Met inhibitors as anticancer agents US Patent  US9695175 Publication Date 7/4/2017 
Target
Name:
Hepatocyte growth factor receptor [1038-1346]
Synonyms:
Hepatocyte growth factor receptor (MET) | MET | MET_HUMAN
Type:
n/a
Mol. Mass.:
34804.00
Organism:
Homo sapiens (Human)
Description:
c-Met kinase (1038-1346 aa)
Residue:
309
Sequence:
GDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIG
  
Inhibitor
Name:
BDBM107317
Synonyms:
US9695175, 47
Type:
Small organic molecule
Emp. Form.:
C20H15F3N8
Mol. Mass.:
424.3819
SMILES:
Cn1cc2cc(c(F)cc2n1)C(F)(F)c1nnc2ncc(cn12)-c1cnn(c1)C1CC1
Structure:
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