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TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial
LigandBDBM273013
Substrate/Competitorn/a
Meas. Tech.KAT-II inhibitory assay
pH8±n/a
IC50 6200±n/a nM
Commentsextracted
Citation Okuyama, MFukunaga, KUsui, KHayashi, NIijima, DHoriuchi, HItagaki, N Bicyclic or tricyclic heterocyclic compound US Patent US10065972 Publication Date 9/4/2018
More Info.:Get all data from this article,  Assay Method
 
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Name:Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Synonyms:2-aminoadipate aminotransferase | 2-aminoadipate transaminase | AADAT | Alpha-aminoadipate aminotransferase | KAT/AadAT | KAT2 | Kynurenine aminotransferase II | Kynurenine aminotransferase II (KAT II) | Kynurenine--oxoglutarate aminotransferase II | Kynurenine--oxoglutarate transaminase 2 | Kynurenine--oxoglutarate transaminase II
Type:Enzyme
Mol. Mass.:47353.09
Organism:Homo sapiens (Human)
Description:Q8N5Z0
Residue:425
Sequence:
MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT
IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG
LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP
EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK
FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ
LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV
KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL
IKESL
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BDBM273013
NameBDBM273013
Synonyms:(R)-N-(2-chlorobenzyl)-2-[7-oxo-6-(propan-2-yl)-5-trifluoromethyl-6,7-dihydro[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-1-carboxamide | US10065972, Example 11
TypeSmall organic molecule
Emp. Form.C21H21ClF3N5O2S
Mol. Mass.499.937
SMILESCC(C)n1c(nc2sc(nc2c1=O)[C@H]1CCCN1C(=O)NCc1ccccc1Cl)C(F)(F)F |r|
Structure
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n/a