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TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial
LigandBDBM273075
Substrate/Competitorn/a
Meas. Tech.KAT-II inhibitory assay
pH8±n/a
IC50 14.0±n/a nM
Commentsextracted
Citation Okuyama, MFukunaga, KUsui, KHayashi, NIijima, DHoriuchi, HItagaki, N Bicyclic or tricyclic heterocyclic compound US Patent US10065972 Publication Date 9/4/2018
More Info.:Get all data from this article,  Assay Method
 
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Name:Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Synonyms:2-aminoadipate aminotransferase | 2-aminoadipate transaminase | AADAT | Alpha-aminoadipate aminotransferase | KAT/AadAT | KAT2 | Kynurenine aminotransferase II | Kynurenine aminotransferase II (KAT II) | Kynurenine--oxoglutarate aminotransferase II | Kynurenine--oxoglutarate transaminase 2 | Kynurenine--oxoglutarate transaminase II
Type:Enzyme
Mol. Mass.:47353.09
Organism:Homo sapiens (Human)
Description:Q8N5Z0
Residue:425
Sequence:
MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT
IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG
LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP
EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK
FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ
LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV
KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL
IKESL
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BDBM273075
NameBDBM273075
Synonyms:(R)-N-benzyl-1-[6-methyl-7-oxo-5-(2,4,6-trifluorophenyl)-6,7-dihydro[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2-carboxamide | US10065972, Example 203
TypeSmall organic molecule
Emp. Form.C24H20F3N5O2S
Mol. Mass.499.508
SMILESCn1c(nc2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1)-c1c(F)cc(F)cc1F |r,wD:15.18,(5.33,-.08,;4,-.85,;4,-2.39,;2.66,-3.16,;1.33,-2.39,;-.14,-2.87,;-1.04,-1.62,;-.14,-.37,;1.33,-.85,;2.66,-.08,;2.66,1.46,;-2.58,-1.62,;-3.49,-2.87,;-4.95,-2.39,;-4.95,-.85,;-3.49,-.37,;-3.09,1.11,;-1.6,1.51,;-4.18,2.2,;-5.66,1.8,;-6.75,2.89,;-6.36,4.38,;-7.44,5.47,;-8.93,5.07,;-9.33,3.58,;-8.24,2.49,;5.33,-3.16,;5.33,-4.7,;4,-5.47,;6.66,-5.47,;8,-4.7,;9.33,-5.47,;8,-3.16,;6.66,-2.39,;7.43,-1.06,)|
Structure
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