Reaction Details Report a problem with these data
Target
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Ligand
BDBM273113
Substrate
n/a
Meas. Tech.
KAT-II inhibitory assay
pH
8±n/a
IC50
49.0±n/a nM
Comments
extracted
Citation
 Okuyama, M; Fukunaga, K; Usui, K; Hayashi, N; Iijima, D; Horiuchi, H; Itagaki, N Bicyclic or tricyclic heterocyclic compound US Patent  US10065972 Publication Date 9/4/2018 
Target
Name:
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Synonyms:
2-aminoadipate aminotransferase | 2-aminoadipate transaminase | AADAT | AADAT_HUMAN | Alpha-aminoadipate aminotransferase | KAT/AadAT | KAT2 | KYAT2 | Kynurenine aminotransferase II | Kynurenine aminotransferase II (KAT II) | Kynurenine--oxoglutarate aminotransferase II | Kynurenine--oxoglutarate transaminase 2 | Kynurenine--oxoglutarate transaminase II
Type:
Enzyme
Mol. Mass.:
47353.09
Organism:
Homo sapiens (Human)
Description:
Q8N5Z0
Residue:
425
Sequence:
MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNKFRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKESL
  
Inhibitor
Name:
BDBM273113
Synonyms:
(R)-N-benzyl-1-[6-methyl-5-{[N'-methyl-N'-(2,2,2-trifluoroethyl)amino]methyl}-7-oxo-6,7-dihydro[1,3]thiazolo[5,4-d]pyrimidin-2-yl]pyrrolidine-2-carboxamide | US10065972, Example 333
Type:
Small organic molecule
Emp. Form.:
C22H25F3N6O2S
Mol. Mass.:
494.533
SMILES:
CN(Cc1nc2sc(nc2c(=O)n1C)N1CCC[C@@H]1C(=O)NCc1ccccc1)CC(F)(F)F |r|
Structure:
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