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TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial
LigandBDBM273158
Substrate/Competitorn/a
Meas. Tech.KAT-II inhibitory assay
pH8±n/a
IC50 8.20±n/a nM
Commentsextracted
Citation Okuyama, MFukunaga, KUsui, KHayashi, NIijima, DHoriuchi, HItagaki, N Bicyclic or tricyclic heterocyclic compound US Patent US10065972 Publication Date 9/4/2018
More Info.:Get all data from this article,  Assay Method
 
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Name:Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Synonyms:2-aminoadipate aminotransferase | 2-aminoadipate transaminase | AADAT | Alpha-aminoadipate aminotransferase | KAT/AadAT | KAT2 | Kynurenine aminotransferase II | Kynurenine aminotransferase II (KAT II) | Kynurenine--oxoglutarate aminotransferase II | Kynurenine--oxoglutarate transaminase 2 | Kynurenine--oxoglutarate transaminase II
Type:Enzyme
Mol. Mass.:47353.09
Organism:Homo sapiens (Human)
Description:Q8N5Z0
Residue:425
Sequence:
MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT
IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG
LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP
EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK
FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ
LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV
KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL
IKESL
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BDBM273158
NameBDBM273158
Synonyms:(R)-N-benzyl-1-(5,5-difluoro-10-oxo-5,7,8,10-tetrahydro-6H-pyrido[1,2-a][1,3]thiazolo[5,4-d]pyrimidin-2-yl)pyrrolidine-2-carboxamide | US10065972, Example 605
TypeSmall organic molecule
Emp. Form.C21H21F2N5O2S
Mol. Mass.445.486
SMILESFC1(F)CCCn2c1nc1sc(nc1c2=O)N1CCC[C@@H]1C(=O)NCc1ccccc1 |r|
Structure
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n/a