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Target
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Ligand
BDBM80289
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay
IC50
1734±109 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay PubChem Bioassay (2011)[AID] 
Target
Name:
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Synonyms:
CTDS1_HUMAN | CTDSP1 | NIF3 | NLIIF | SCP1 | carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29199.89
Organism:
Homo sapiens (Human)
Description:
gi_10864009
Residue:
261
Sequence:
MDSSAVITQISKEEARGPLRGKGDQKSAASQKPRSRGILHSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKQTPVQYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS
  
Inhibitor
Name:
BDBM80289
Synonyms:
(8S)-3-(3-methacrylamidophenyl)-7-[(E)-pent-2-enoyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide | (8S)-3-[3-(2-methylprop-2-enoylamino)phenyl]-7-[(E)-pent-2-enoyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide | (8S)-3-[3-[(2-methyl-1-oxoprop-2-enyl)amino]phenyl]-7-[(E)-1-oxopent-2-enyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide | MLS000562001 | SMR000390637 | cid_16745457
Type:
Small organic molecule
Emp. Form.:
C22H26N4O4
Mol. Mass.:
410.4662
SMILES:
CC\C=C\C(=O)N1CC2(C[C@H]1C(N)=O)CC(=NO2)c1cccc(NC(=O)C(C)=C)c1 |c:16|
Structure:
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