Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM62545
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM62545
Synonyms:
3-amino-8-methyl-2-thieno[2,3-b]quinolinecarbonitrile | 3-amino-8-methyl-thieno[2,3-b]quinoline-2-carbonitrile | 3-amino-8-methylthieno[2,3-b]quinoline-2-carbonitrile | 3-azanyl-8-methyl-thieno[2,3-b]quinoline-2-carbonitrile | MLS000072566 | SMR000001748 | cid_649697
Type:
Small organic molecule
Emp. Form.:
C13H9N3S
Mol. Mass.:
239.296
SMILES:
Cc1cccc2cc3c(N)c(sc3nc12)C#N
Structure:
Search PDB for entries with ligand similarity: