Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83477
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83477
Synonyms:
2-amino-7-keto-8,10-dimethyl-4-phenyl-4H-furo[1,2]cyclohepta[4,6-d]pyran-3-carbonitrile | 2-amino-8,10-dimethyl-7-oxo-4-phenyl-4H-furo[1,2]cyclohepta[4,6-d]pyran-3-carbonitrile | 2-azanyl-8,10-dimethyl-7-oxidanylidene-4-phenyl-4H-furo[1,2]cyclohepta[4,6-d]pyran-3-carbonitrile | MLS000042791 | SMR000046489 | cid_665296
Type:
Small organic molecule
Emp. Form.:
C21H16N2O3
Mol. Mass.:
344.3633
SMILES:
Cc1oc(C)c2c1c1OC(=N)C(C#N)C(c3ccccc3)c1ccc2=O
Structure:
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