Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83583
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83583
Synonyms:
MLS000402293 | N-ethyl-N-[2-[(5-nitro-8-quinolinyl)amino]ethyl]benzenesulfonamide | N-ethyl-N-[2-[(5-nitro-8-quinolyl)amino]ethyl]benzenesulfonamide | N-ethyl-N-[2-[(5-nitroquinolin-8-yl)amino]ethyl]benzenesulfonamide | SMR000243000 | cid_2920050
Type:
Small organic molecule
Emp. Form.:
C19H20N4O4S
Mol. Mass.:
400.451
SMILES:
CCN(CCNc1ccc([N+]([O-])=O)c2cccnc12)S(=O)(=O)c1ccccc1
Structure:
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