Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83701
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83701
Synonyms:
(Z)-2-cyano-N-(2-fluorophenyl)-3-[(3E)-2-(4-morpholinyl)-3-[(3-nitrophenyl)methylidene]-1-cyclopentenyl]-2-propenamide | (Z)-2-cyano-N-(2-fluorophenyl)-3-[(3E)-2-morpholin-4-yl-3-[(3-nitrophenyl)methylidene]cyclopenten-1-yl]prop-2-enamide | (Z)-2-cyano-N-(2-fluorophenyl)-3-[(3E)-2-morpholino-3-(3-nitrobenzylidene)cyclopenten-1-yl]acrylamide | MLS002635909 | SMR001544559 | cid_2338341
Type:
Small organic molecule
Emp. Form.:
C26H23FN4O4
Mol. Mass.:
474.4836
SMILES:
[O-][N+](=O)c1cccc(\C=C2/CCC(\C=C(\C#N)C(=O)Nc3ccccc3F)=C2N2CCOCC2)c1 |c:27|
Structure:
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