Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM49192
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
48400±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM49192
Synonyms:
(3-Cyano-7-methoxy-quinolin-2-ylsulfanyl)-acetic acid methyl ester | 2-[(3-cyano-7-methoxy-2-quinolinyl)thio]acetic acid methyl ester | 2-[(3-cyano-7-methoxy-2-quinolyl)thio]acetic acid methyl ester | MLS000070306 | SMR000001741 | cid_656385 | methyl 2-(3-cyano-7-methoxy-quinolin-2-yl)sulfanylethanoate | methyl 2-(3-cyano-7-methoxyquinolin-2-yl)sulfanylacetate
Type:
Small organic molecule
Emp. Form.:
C14H12N2O3S
Mol. Mass.:
288.322
SMILES:
COC(=O)CSc1nc2cc(OC)ccc2cc1C#N
Structure:
Search PDB for entries with ligand similarity: