Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM50789
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
50700±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM50789
Synonyms:
2-(9-methoxy-6-indolo[3,2-b]quinoxalinyl)acetic acid ethyl ester | 2-(9-methoxyindolo[3,2-b]quinoxalin-6-yl)acetic acid ethyl ester | MLS000040505 | SMR000043303 | cid_662543 | ethyl 2-(9-methoxyindolo[3,2-b]quinoxalin-6-yl)acetate | ethyl 2-(9-methoxyindolo[3,2-b]quinoxalin-6-yl)ethanoate
Type:
Small organic molecule
Emp. Form.:
C19H17N3O3
Mol. Mass.:
335.3566
SMILES:
CCOC(=O)Cn1c2ccc(OC)cc2c2nc3ccccc3nc12
Structure:
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