Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM31705
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
30900±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM31705
Synonyms:
3-(1-benzofuran-2-yl)-1-ethoxy-2(1H)-quinoxalinone 4-oxide | 3-(1-benzofuran-2-yl)-1-ethoxy-4-oxidanidyl-quinoxalin-4-ium-2-one | 3-(1-benzofuran-2-yl)-1-ethoxy-4-oxidoquinoxalin-4-ium-2-one | 3-(2-benzofuranyl)-1-ethoxy-4-oxido-2-quinoxalin-4-iumone | 3-(benzofuran-2-yl)-1-ethoxy-4-oxido-quinoxalin-4-ium-2-one | MLS000063653 | SMR000075322 | cid_951071
Type:
Small organic molecule
Emp. Form.:
C18H14N2O4
Mol. Mass.:
322.3148
SMILES:
CCOn1c2ccccc2[n+]([O-])c(-c2cc3ccccc3o2)c1=O
Structure:
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