Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM33099
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM33099
Synonyms:
2-[[(5E)-5-(4-acetoxybenzylidene)-4-keto-2-thiazolin-2-yl]thio]acetic acid ethyl ester | 2-[[(5E)-5-[(4-acetyloxyphenyl)methylidene]-4-oxo-2-thiazolyl]thio]acetic acid ethyl ester | MLS000327789 | SMR000180755 | cid_5927217 | ethyl 2-[(5-{(E)-[4-(acetyloxy)phenyl]methylidene}-4-oxo-4,5-dihydro-1,3-thiazol-2-yl)sulfanyl]acetate | ethyl 2-[[(5E)-5-[(4-acetyloxyphenyl)methylidene]-4-oxidanylidene-1,3-thiazol-2-yl]sulfanyl]ethanoate | ethyl 2-[[(5E)-5-[(4-acetyloxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]sulfanyl]acetate
Type:
Small organic molecule
Emp. Form.:
C16H15NO5S2
Mol. Mass.:
365.424
SMILES:
CCOC(=O)CSC1=NC(=O)\C(S1)=C/c1ccc(OC(C)=O)cc1 |t:7|
Structure:
Search PDB for entries with ligand similarity: