Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM63376
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
85100±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM63376
Synonyms:
2-(2,3-dihydro-1,4-benzodioxin-3-ylcarbonylamino)-6-(phenylmethyl)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide;hydrochloride | 2-[[2,3-dihydro-1,4-benzodioxin-3-yl(oxo)methyl]amino]-6-(phenylmethyl)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide;hydrochloride | 6-benzyl-2-(2,3-dihydro-1,4-benzodioxin-3-carbonylamino)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide;hydrochloride | 6-benzyl-2-(2,3-dihydro-1,4-benzodioxine-3-carbonylamino)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide;hydrochloride | MLS000683233 | SMR000323052 | cid_16187087
Type:
Small organic molecule
Emp. Form.:
C24H23N3O4S
Mol. Mass.:
449.522
SMILES:
NC(=O)c1c(NC(=O)C2COc3ccccc3O2)sc2CN(Cc3ccccc3)CCc12
Structure:
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