Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM61621
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM61621
Synonyms:
(5Z)-3-(2-methoxyethyl)-5-(4-pyrrolidinobenzylidene)-2-thioxo-thiazolidin-4-one | (5Z)-3-(2-methoxyethyl)-5-[(4-pyrrolidin-1-ylphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one | (5Z)-3-(2-methoxyethyl)-5-[[4-(1-pyrrolidinyl)phenyl]methylidene]-2-sulfanylidene-4-thiazolidinone | 3-(2-methoxyethyl)-5-[4-(1-pyrrolidinyl)benzylidene]-2-thioxo-1,3-thiazolidin-4-one | MLS000662507 | SMR000292273 | cid_2189900
Type:
Small organic molecule
Emp. Form.:
C17H20N2O2S2
Mol. Mass.:
348.483
SMILES:
COCCN1C(=S)S\C(=C/c2ccc(cc2)N2CCCC2)C1=O
Structure:
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