Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83625
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
35900±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83625
Synonyms:
2-(phenacylthio)-6-(3-pyridinyl)-3-pyridinecarbonitrile | 2-(phenacylthio)-6-(3-pyridyl)nicotinonitrile | 2-phenacylsulfanyl-6-pyridin-3-yl-pyridine-3-carbonitrile | 2-phenacylsulfanyl-6-pyridin-3-ylpyridine-3-carbonitrile | 6-(2-Oxo-2-phenyl-ethylsulfanyl)-[2,3']bipyridinyl-5-carbonitrile | MLS000779929 | SMR000420098 | cid_682310
Type:
Small organic molecule
Emp. Form.:
C19H13N3OS
Mol. Mass.:
331.391
SMILES:
O=C(CSc1nc(ccc1C#N)-c1cccnc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: