Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM53222
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
16300±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM53222
Synonyms:
(5E)-1-(4-ethoxyphenyl)-5-(1H-indol-3-ylmethylene)pyrimidine-2,4,6(1H,3H,5H)-trione | (5E)-1-(4-ethoxyphenyl)-5-(1H-indol-3-ylmethylidene)-1,3-diazinane-2,4,6-trione | (5E)-5-(1H-indol-3-ylmethylene)-1-p-phenetyl-barbituric acid | MLS001194999 | SMR000554645 | cid_24762080
Type:
Small organic molecule
Emp. Form.:
C21H17N3O4
Mol. Mass.:
375.3774
SMILES:
CCOc1ccc(cc1)N1C(=O)NC(=O)C(=Cc2c[nH]c3ccccc23)C1=O |w:16.17|
Structure:
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