Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83709
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
3550±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83709
Synonyms:
(2,4-dinitrophenyl)-methyl-(8-quinolylmethyleneamino)amine | MLS002701642 | N-methyl-2,4-dinitro-N-(8-quinolinylmethylideneamino)aniline | N-methyl-2,4-dinitro-N-(quinolin-8-ylmethylideneamino)aniline | SMR001565243 | cid_364424
Type:
Small organic molecule
Emp. Form.:
C17H13N5O4
Mol. Mass.:
351.3162
SMILES:
CN(\N=C\c1cccc2cccnc12)c1ccc(cc1[N+]([O-])=O)[N+]([O-])=O
Structure:
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