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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM83725
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59616±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM83725
Synonyms:
2-[2-methyl-1-[1-(tosylmethyl)tetrazol-5-yl]propyl]-3,4-dihydro-1H-isoquinoline | 2-[2-methyl-1-[1-[(4-methylphenyl)sulfonylmethyl]-1,2,3,4-tetrazol-5-yl]propyl]-3,4-dihydro-1H-isoquinoline | 2-[2-methyl-1-[1-[(4-methylphenyl)sulfonylmethyl]-5-tetrazolyl]propyl]-3,4-dihydro-1H-isoquinoline | 2-[2-methyl-1-[1-[(4-methylphenyl)sulfonylmethyl]tetrazol-5-yl]propyl]-3,4-dihydro-1H-isoquinoline | 2-{2-Methyl-1-[1-(toluene-4-sulfonylmethyl)-1H-tetrazol-5-yl]-propyl}-1,2,3,4-tetrahydro-isoquinoline | MLS000032485 | SMR000003740 | cid_654651
Type:
Small organic molecule
Emp. Form.:
C22H27N5O2S
Mol. Mass.:
425.547
SMILES:
CC(C)C(N1CCc2ccccc2C1)c1nnnn1CS(=O)(=O)c1ccc(C)cc1
Structure:
Search PDB for entries with ligand similarity: