Reaction Details Report a problem with these data
Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM41394
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59620±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM41394
Synonyms:
5-(2,5-dimethoxyphenyl)-N-[3,5-dimethyl-1-(phenylmethyl)-4-pyrazolyl]-3-isoxazolecarboxamide | 5-(2,5-dimethoxyphenyl)-N-[3,5-dimethyl-1-(phenylmethyl)pyrazol-4-yl]-1,2-oxazole-3-carboxamide | MLS000087188 | N-(1-benzyl-3,5-dimethyl-1H-pyrazol-4-yl)-5-(2,5-dimethoxyphenyl)isoxazole-3-carboxamide | N-(1-benzyl-3,5-dimethyl-pyrazol-4-yl)-5-(2,5-dimethoxyphenyl)isoxazole-3-carboxamide | N-(1-benzyl-3,5-dimethylpyrazol-4-yl)-5-(2,5-dimethoxyphenyl)-1,2-oxazole-3-carboxamide | SMR000023411 | cid_3236902
Type:
Small organic molecule
Emp. Form.:
C24H24N4O4
Mol. Mass.:
432.4718
SMILES:
COc1ccc(OC)c(c1)-c1cc(no1)C(=O)Nc1c(C)nn(Cc2ccccc2)c1C
Structure:
Search PDB for entries with ligand similarity: