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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM77099
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59633±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM77099
Synonyms:
2-N,2-N,7-N,7-N-tetraethyl-9-hydroxyiminofluorene-2,7-disulfonamide | 9-Hydroxyimino-9H-fluorene-2,7-disulfonic acid bis-diethylamide | MLS000035505 | N,N,N',N'-tetraethyl-9-hydroximino-fluorene-2,7-disulfonamide | N2,N2,N7,N7-tetraethyl-9-hydroxyimino-fluorene-2,7-disulfonamide | N2,N2,N7,N7-tetraethyl-9-hydroxyiminofluorene-2,7-disulfonamide | SMR000123093 | cid_1204412
Type:
Small organic molecule
Emp. Form.:
C21H27N3O5S2
Mol. Mass.:
465.586
SMILES:
CCN(CC)S(=O)(=O)c1ccc-2c(c1)C(N=O)c1cc(ccc-21)S(=O)(=O)N(CC)CC
Structure:
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