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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM83747
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59616±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM83747
Synonyms:
1-Amino-5-ethyl-6,7,8,9-tetrahydro-thieno[2,3-c]isoquinoline-2-carbonitrile | 1-amino-5-ethyl-6,7,8,9-tetrahydrothien[2,3-c]isoquinoline-2-carbonitrile | 1-amino-5-ethyl-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carbonitrile | 1-azanyl-5-ethyl-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carbonitrile | MLS000525643 | SMR000116117 | cid_770124
Type:
Small organic molecule
Emp. Form.:
C14H15N3S
Mol. Mass.:
257.354
SMILES:
CCc1nc2sc(C#N)c(N)c2c2CCCCc12
Structure:
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