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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM83758
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59649±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM83758
Synonyms:
(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-acetic acid 2,2,4-trimethyl-1,2-dihydro-quinolin-6-yl ester | (2,2,4-trimethyl-1H-quinolin-6-yl) 2-(1,3-dioxoisoindol-2-yl)acetate | (2,2,4-trimethyl-1H-quinolin-6-yl) 2-[1,3-bis(oxidanylidene)isoindol-2-yl]ethanoate | 2-(1,3-dioxo-2-isoindolyl)acetic acid (2,2,4-trimethyl-1H-quinolin-6-yl) ester | 2-phthalimidoacetic acid (2,2,4-trimethyl-1H-quinolin-6-yl) ester | MLS000557207 | SMR000175619 | cid_996076
Type:
Small organic molecule
Emp. Form.:
C22H20N2O4
Mol. Mass.:
376.4052
SMILES:
CC1=CC(C)(C)Nc2ccc(OC(=O)CN3C(=O)c4ccccc4C3=O)cc12 |t:1|
Structure:
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