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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM42064
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59641±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM42064
Synonyms:
1-[1-(2-chlorophenyl)-2-keto-cyclohexyl]-3-cyclohexyl-1-methyl-thiourea | 1-[1-(2-chlorophenyl)-2-oxidanylidene-cyclohexyl]-3-cyclohexyl-1-methyl-thiourea | 1-[1-(2-chlorophenyl)-2-oxocyclohexyl]-3-cyclohexyl-1-methylthiourea | MLS000391056 | SMR000260093 | cid_4006073
Type:
Small organic molecule
Emp. Form.:
C20H27ClN2OS
Mol. Mass.:
378.959
SMILES:
CN(C(=S)NC1CCCCC1)C1(CCCCC1=O)c1ccccc1Cl
Structure:
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