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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM68128
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59592±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM68128
Synonyms:
1-chloranyl-7,8-bis(fluoranyl)-3-methyl-pyrido[1,2-a]benzimidazole-4-carbonitrile | 1-chloro-7,8-difluoro-3-methyl-4-pyrido[1,2-a]benzimidazolecarbonitrile | 1-chloro-7,8-difluoro-3-methyl-pyrido[1,2-a]benzimidazole-4-carbonitrile | 1-chloro-7,8-difluoro-3-methylpyrido[1,2-a]benzimidazole-4-carbonitrile | MLS000729184 | SMR000307462 | cid_1507407
Type:
Small organic molecule
Emp. Form.:
C13H6ClF2N3
Mol. Mass.:
277.657
SMILES:
Cc1cc(Cl)n2c(nc3cc(F)c(F)cc23)c1C#N
Structure:
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