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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM83825
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59585±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM83825
Synonyms:
MLS002170809 | N-(1,3-benzodioxol-5-yl)-2-(4,5-dichloro-6-keto-pyridazin-1-yl)acetamide | N-(1,3-benzodioxol-5-yl)-2-(4,5-dichloro-6-oxo-1-pyridazinyl)acetamide | N-(1,3-benzodioxol-5-yl)-2-(4,5-dichloro-6-oxopyridazin-1-yl)acetamide | N-(1,3-benzodioxol-5-yl)-2-[4,5-bis(chloranyl)-6-oxidanylidene-pyridazin-1-yl]ethanamide | SMR001251119 | cid_2647474
Type:
Small organic molecule
Emp. Form.:
C13H9Cl2N3O4
Mol. Mass.:
342.134
SMILES:
Clc1cnn(CC(=O)Nc2ccc3OCOc3c2)c(=O)c1Cl
Structure:
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