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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM76777
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59638±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM76777
Synonyms:
7-[2-(3,5-dimethoxyphenyl)ethynyl]-3-(3-hydroxypropyl)-2-benzopyran-1-one | 7-[2-(3,5-dimethoxyphenyl)ethynyl]-3-(3-hydroxypropyl)isochromen-1-one | 7-[2-(3,5-dimethoxyphenyl)ethynyl]-3-(3-hydroxypropyl)isocoumarin | 7-[2-(3,5-dimethoxyphenyl)ethynyl]-3-(3-oxidanylpropyl)isochromen-1-one | MLS002402814 | SMR001370582 | cid_44142298
Type:
Small organic molecule
Emp. Form.:
C22H20O5
Mol. Mass.:
364.3912
SMILES:
COc1cc(OC)cc(c1)C#Cc1ccc2cc(CCCO)oc(=O)c2c1
Structure:
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