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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM83829
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59538±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM83829
Synonyms:
4,5-bis(chloranyl)-2-[2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-oxidanylidene-ethyl]pyridazin-3-one;ethanedioic acid | 4,5-dichloro-2-[2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-keto-ethyl]pyridazin-3-one;oxalic acid | 4,5-dichloro-2-[2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-oxoethyl]-3-pyridazinone;oxalic acid | 4,5-dichloro-2-[2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-oxoethyl]pyridazin-3-one;oxalic acid | MLS002244764 | SMR001308437 | cid_16247248
Type:
Small organic molecule
Emp. Form.:
C14H10Cl2N2O4
Mol. Mass.:
341.146
SMILES:
Clc1cnn(CC(=O)c2ccc3OCCOc3c2)c(=O)c1Cl
Structure:
Search PDB for entries with ligand similarity: