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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM83835
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59638±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM83835
Synonyms:
2-amino-4-[(4-cyanobenzyl)thio]-1-(4-phenylthiazol-2-yl)-3-azaspiro[5.5]undeca-2,4-diene-5-carbonitrile | 2-amino-4-[(4-cyanophenyl)methylsulfanyl]-1-(4-phenyl-1,3-thiazol-2-yl)-3-azaspiro[5.5]undeca-2,4-diene-5-carbonitrile | 2-amino-4-[(4-cyanophenyl)methylthio]-1-(4-phenyl-2-thiazolyl)-3-azaspiro[5.5]undeca-2,4-diene-5-carbonitrile | 2-azanyl-4-[(4-cyanophenyl)methylsulfanyl]-1-(4-phenyl-1,3-thiazol-2-yl)-3-azaspiro[5.5]undeca-2,4-diene-5-carbonitrile | MLS002634876 | SMR000154115 | cid_4840090
Type:
Small organic molecule
Emp. Form.:
C28H25N5S2
Mol. Mass.:
495.662
SMILES:
NC1=NC(SCc2ccc(cc2)C#N)=C(C#N)C2(CCCCC2)C1c1nc(cs1)-c1ccccc1 |t:1,14|
Structure:
Search PDB for entries with ligand similarity: