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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM83864
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59649±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM83864
Synonyms:
3-(5-acetyl-2-methoxy-benzyl)-5-(2-methoxyphenyl)-3-methyl-oxindole | 3-[(5-acetyl-2-methoxyphenyl)methyl]-5-(2-methoxyphenyl)-3-methyl-1H-indol-2-one | 3-[(5-ethanoyl-2-methoxy-phenyl)methyl]-5-(2-methoxyphenyl)-3-methyl-1H-indol-2-one | MLS003121938 | SMR001453871 | cid_46948223
Type:
Small organic molecule
Emp. Form.:
C26H25NO4
Mol. Mass.:
415.481
SMILES:
COc1ccc(cc1CC1(C)C(=O)Nc2ccc(cc12)-c1ccccc1OC)C(C)=O
Structure:
Search PDB for entries with ligand similarity: