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Reaction Details
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TargetCaspase-9
LigandBDBM34676
Substrate/Competitorn/a
Meas. Tech.Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay
IC50 10900±n/a nM
Citation PubChem, PC Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay PubChem Bioassay(2011)[AID]  Article
More Info.:Get all data from this article,  Assay Method
 
Caspase-9
Name:Caspase-9
Synonyms:Apoptotic protease-activating factor 3 | CASP-9 | Caspase 9 | ICE-like apoptotic protease 6 | caspase-9 isoform alpha preproprotein
Type:Enzyme
Mol. Mass.:46277.29
Organism:Homo sapiens (human)
Description:n/a
Residue:416
Sequence:
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR
TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ
ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS
TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG
SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
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  Blast E-value cutoff:
BDBM34676
n/a
NameBDBM34676
Synonyms:1-amyl-2-(2-furoylamino)pyrrolo[3,2-b]quinoxaline-3-carboxylic acid ethyl ester | 2-[(Furan-2-carbonyl)-amino]-1-pentyl-1H-pyrrolo[2,3-b]quinoxaline-3-carboxylic acid ethyl ester | 2-[[2-furanyl(oxo)methyl]amino]-1-pentyl-3-pyrrolo[3,2-b]quinoxalinecarboxylic acid ethyl ester | MLS000555532 | SMR000147249 | cid_1951332 | ethyl 2-(furan-2-carbonylamino)-1-pentylpyrrolo[3,2-b]quinoxaline-3-carboxylate | ethyl 2-(furan-2-ylcarbonylamino)-1-pentyl-pyrrolo[3,2-b]quinoxaline-3-carboxylate
TypeSmall organic molecule
Emp. Form.C23H24N4O4
Mol. Mass.420.4611
SMILESCCCCCn1c(NC(=O)c2ccco2)c(C(=O)OCC)c2nc3ccccc3nc12
Structure
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