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Target
Caspase-9
Ligand
BDBM70568
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay
IC50
10100±n/a nM
Citation
 PubChem, PC Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay PubChem Bioassay (2011)[AID] 
Target
Name:
Caspase-9
Synonyms:
Apoptotic protease-activating factor 1/Caspase-3/Caspase-9/Cytochrome c | Apoptotic protease-activating factor 3 | CASP-9 | CASP9 | CASP9_HUMAN | Caspase 9 | ICE-like apoptotic protease 6 | MCH6 | caspase-9 isoform alpha preproprotein
Type:
Enzyme
Mol. Mass.:
46277.29
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
416
Sequence:
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
  
Inhibitor
Name:
BDBM70568
Synonyms:
MLS000550969 | N-(4-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-1,4-dioxo-1,4-dihydro-naphthalen-2-ylsulfamoyl}-phenyl)-ac etamide | N-[4-[[3-[4-(4-fluorophenyl)-1-piperazinyl]-1,4-dioxo-2-naphthalenyl]sulfamoyl]phenyl]acetamide | N-[4-[[3-[4-(4-fluorophenyl)piperazin-1-yl]-1,4-bis(oxidanylidene)naphthalen-2-yl]sulfamoyl]phenyl]ethanamide | N-[4-[[3-[4-(4-fluorophenyl)piperazin-1-yl]-1,4-dioxonaphthalen-2-yl]sulfamoyl]phenyl]acetamide | N-[4-[[3-[4-(4-fluorophenyl)piperazino]-1,4-diketo-2-naphthyl]sulfamoyl]phenyl]acetamide | SMR000145097 | cid_4261850
Type:
Small organic molecule
Emp. Form.:
C28H25FN4O5S
Mol. Mass.:
548.585
SMILES:
CC(=O)Nc1ccc(cc1)S(=O)(=O)NC1=C(N2CCN(CC2)c2ccc(F)cc2)C(=O)c2ccccc2C1=O |c:15|
Structure:
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