Reaction Details Report a problem with these data
Target
Caspase-9
Ligand
BDBM61198
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay
IC50
2630±n/a nM
Citation
 PubChem, PC Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay PubChem Bioassay (2011)[AID] 
Target
Name:
Caspase-9
Synonyms:
Apoptotic protease-activating factor 1/Caspase-3/Caspase-9/Cytochrome c | Apoptotic protease-activating factor 3 | CASP-9 | CASP9 | CASP9_HUMAN | Caspase 9 | ICE-like apoptotic protease 6 | MCH6 | caspase-9 isoform alpha preproprotein
Type:
Enzyme
Mol. Mass.:
46277.29
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
416
Sequence:
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
  
Inhibitor
Name:
BDBM61198
Synonyms:
2-methoxybenzaldehyde [2,6-bis(dimethylamino)pyrimidin-4-yl]hydrazone | 6-N-[(2-methoxyphenyl)methylideneamino]-2-N,2-N,4-N,4-N-tetramethylpyrimidine-2,4,6-triamine | MLS000720211 | N6-[(2-methoxyphenyl)methylideneamino]-N2,N2,N4,N4-tetramethyl-pyrimidine-2,4,6-triamine | N6-[(2-methoxyphenyl)methylideneamino]-N2,N2,N4,N4-tetramethylpyrimidine-2,4,6-triamine | SMR000304740 | [2-(dimethylamino)-6-(N'-o-anisylidenehydrazino)pyrimidin-4-yl]-dimethyl-amine | cid_4035805
Type:
Small organic molecule
Emp. Form.:
C16H22N6O
Mol. Mass.:
314.3855
SMILES:
COc1ccccc1CN=Nc1cc(nc(n1)N(C)C)N(C)C |w:10.11|
Structure:
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