Reaction Details Report a problem with these data
Target
Sentrin-specific protease 8
Ligand
BDBM84062
Substrate
n/a
Meas. Tech.
SAR Analysis of small molecule inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay - Set 2
IC50
>99000±n/a nM
Citation
 PubChem, PC SAR Analysis of small molecule inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay - Set 2 PubChem Bioassay (2011)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM84062
Synonyms:
4-[2-[(Z)-indol-3-ylidenemethyl]hydrazinyl]-N-(2-methylphenyl)-4-oxidanylidene-butanamide | 4-[2-[(Z)-indol-3-ylidenemethyl]hydrazinyl]-N-(2-methylphenyl)-4-oxobutanamide | 4-[N'-[(Z)-indol-3-ylidenemethyl]hydrazino]-4-keto-N-(o-tolyl)butyramide | 4-[[(Z)-3-indolylidenemethyl]hydrazo]-N-(2-methylphenyl)-4-oxobutanamide | MLS-0454616.0002 | cid_5993267
Type:
Small organic molecule
Emp. Form.:
C20H20N4O2
Mol. Mass.:
348.3984
SMILES:
Cc1ccccc1NC(=O)CCC(=O)NN=Cc1c[nH]c2ccccc12 |w:15.15|
Structure:
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