Reaction Details Report a problem with these data
Target
Sentrin-specific protease 8
Ligand
BDBM84075
Substrate
n/a
Meas. Tech.
SAR Analysis of small molecule inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay - Set 2
IC50
>99000±n/a nM
Citation
 PubChem, PC SAR Analysis of small molecule inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay - Set 2 PubChem Bioassay (2011)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM84075
Synonyms:
1-(2-methoxyphenyl)-3-[[(Z)-(5-piperidin-1-ylsulfonylindol-3-ylidene)methyl]amino]thiourea | 1-(2-methoxyphenyl)-3-[[(Z)-(5-piperidinosulfonylindol-3-ylidene)methyl]amino]thiourea | 1-(2-methoxyphenyl)-3-[[(Z)-[5-(1-piperidinylsulfonyl)-3-indolylidene]methyl]amino]thiourea | MLS-0454628.0002 | cid_12004466
Type:
Small organic molecule
Emp. Form.:
C22H25N5O3S2
Mol. Mass.:
471.596
SMILES:
COc1ccccc1NC(=S)NN=Cc1c[nH]c2ccc(cc12)S(=O)(=O)N1CCCCC1 |w:12.12|
Structure:
Search PDB for entries with ligand similarity: