Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83624
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule activators of the MazEF TA System via a fluorescence-based single-stranded RNase assay
EC50
6200±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule activators of the MazEF TA System via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83624
Synonyms:
3-(3-Hydroxy-propyl)-4-imino-10-phenyl-3,10-dihydro-4H-9-oxa-1,3-diaza-anthracen-7-ol | 3-(3-hydroxypropyl)-4-imino-5-phenyl-5H-[1]benzopyrano[2,3-d]pyrimidin-8-ol | 3-(3-hydroxypropyl)-4-imino-5-phenyl-5H-chromeno[2,3-d]pyrimidin-8-ol | 4-azanylidene-3-(3-oxidanylpropyl)-5-phenyl-5H-chromeno[2,3-d]pyrimidin-8-ol | MLS000778658 | SMR000415452 | cid_4262307
Type:
Small organic molecule
Emp. Form.:
C20H19N3O3
Mol. Mass.:
349.3832
SMILES:
OCCCn1cnc2Oc3cc(O)ccc3C(c3ccccc3)c2c1=N
Structure:
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