Reaction Details Report a problem with these data
Target
Potassium voltage-gated channel subfamily KQT member 2
Ligand
BDBM84175
Substrate
n/a
Meas. Tech.
Dose response assay for compounds that inhibit KCNQ2 potassium channels on automated electrophysiological assay II
IC50
824±482.51 nM
Citation
 PubChem, PC Dose response assay for compounds that inhibit KCNQ2 potassium channels on automated electrophysiological assay II PubChem Bioassay (2011)[AID] 
Target
Name:
Potassium voltage-gated channel subfamily KQT member 2
Synonyms:
KCNQ2_RAT | Kcnq2 | Voltage-gated potassium channel subunit Kv7.2 | potassium voltage-gated channel, KQT-like subfamily, member 2
Type:
PROTEIN
Mol. Mass.:
93984.01
Organism:
Rattus norvegicus
Description:
EBI_100117
Residue:
852
Sequence:
MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMISSQTQTYGASRLIPPLNQLEMLRNLKSKSGLTFRKEPQPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVEDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIPPAETEAYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQRKYAAPPVMPPAECPPSTSWQQSHQRHGTSPVGDHGSLVRIPPPPAHERSLSAYSGGNRASTEFLRLEGTPACRPSEAALRDSDTSISIPSVDHEELERSFSGFSISQSKENLNALASCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVAWAGPRK
  
Inhibitor
Name:
BDBM84175
Synonyms:
MLS000757674 | N-[[5-(diethylsulfamoyl)-2-(4-morpholinyl)anilino]-sulfanylidenemethyl]-2-furancarboxamide | N-[[5-(diethylsulfamoyl)-2-morpholin-4-yl-phenyl]carbamothioyl]furan-2-carboxamide | N-[[5-(diethylsulfamoyl)-2-morpholin-4-ylphenyl]carbamothioyl]furan-2-carboxamide | N-[[5-(diethylsulfamoyl)-2-morpholino-phenyl]thiocarbamoyl]-2-furamide | SMR000371987 | cid_3564701
Type:
Small organic molecule
Emp. Form.:
C20H26N4O5S2
Mol. Mass.:
466.574
SMILES:
CCN(CC)S(=O)(=O)c1ccc(N2CCOCC2)c(NC(=S)NC(=O)c2ccco2)c1
Structure:
Search PDB for entries with ligand similarity: