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Target
D(4) dopamine receptor
Ligand
BDBM84440
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
35.4±0.0 nM
Citation
 Hendrix, JA; Shimshock, SJ; Shutske, GM; Tomer, JD; Kapples, KJ; Palermo, MG; Corbett, TJ; Vargas, HM; Kafka, S; Brooks, KM; Laws-Ricker, L; Lee, DK; de Lannoy, I; Bordeleau, M; Rizkalla, G; Owolabi, J; Kamboj, RK Synthesis and structure-activity relationship of the isoindolinyl benzisoxazolpiperidines as potent, selective, and orally active human dopamine D4 receptor antagonists. Chembiochem 3:999-1009 (2002) [PubMed]  Article 
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM84440
Synonyms:
Isoindoline, 7 | Isoindoline, 8 | Isoindoline, 9
Type:
Small organic molecule
Emp. Form.:
C23H26FN3O2
Mol. Mass.:
395.4698
SMILES:
OCC(CN1Cc2ccccc2C1)N1CCC(CC1)c1noc2cc(F)ccc12
Structure:
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