Target
Alpha-mannosidase 2
Ligand
BDBM84466
Substrate
n/a
pH
5.6±0
Temperature
310.15±0 K
Ki
1.0e+2±n/a nM
Citation
 Li, BKawatkar, SPGeorge, SStrachan, HWoods, RJSiriwardena, AMoremen, KWBoons, GJ Inhibition of Golgi mannosidase II with mannostatin A analogues: synthesis, biological evaluation, and structure-activity relationship studies. Chembiochem 5:1220-7 (2004) [PubMed]  Article 
Target
Name:
Alpha-mannosidase 2
Synonyms:
Alpha-mannosidase 2A1 | Golgi alpha-mannosidase II | Lysosomal acid alpha-mannosidase | MA2A1_HUMAN | MAN2A1 | MANA2 | Mannosidase alpha class 2A member 1 | Mannosidase alpha class 2B member 1 | Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
Type:
Protein
Mol. Mass.:
131156.65
Organism:
Homo sapiens (Human)
Description:
Q16706
Residue:
1144
Sequence:
MKLSRQFTVFGSAIFCVVIFSLYLMLDRGHLDYPRNPRREGSFPQGQLSMLQEKIDHLERLLAENNEIISNIRDSVINLSESVEDGPKSSQSNFSQGAGSHLLPSQLSLSVDTADCLFASQSGSHNSDVQMLDVYSLISFDNPDGGVWKQGFDITYESNEWDTEPLQVFVVPHSHNDPGWLKTFNDYFRDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIENGQLEIVTGGWVMPDEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYLLNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLLAPLGDDFRYCEYTEWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRDKGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESHLRAAEILYYFALRQAHKYKINKFLSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIGNSAFLLILKDKLTYDSYSPDTFLEMDLKQKSQDSLPQKNIIRLSAEPRYLVVYNPLEQDRISLVSVYVSSPTVQVFSASGKPVEVQVSAVWDTANTISETAYEISFRAHIPPLGLKVYKILESASSNSHLADYVLYKNKVEDSGIFTIKNMINTEEGITLENSFVLLRFDQTGLMKQMMTKEDGKHHEVNVQFSWYGTTIKRDKSGAYLFLPDGNAKPYVYTTPPFVRVTHGRIYSEVTCFFDHVTHRVRLYHIQGIEGQSVEVSNIVDIRKVYNREIAMKISSDIKSQNRFYTDLNGYQIQPRMTLSKLPLQANVYPMTTMAYIQDAKHRLTLLSAQSLGVSSLNSGQIEVIMDRRLMQDDNRGLEQGIQDNKITANLFRILLEKRSAVNTEEEKKSVSYPSLLSHITSSLMNHPVIPMANKFSSPTLELQGEFSPLQSSLPCDIHLVNLRTIQSKVGNGHSNEAALILHRKGFDCRFSSKGTGLFCSTTQGKILVQKLLNKFIVESLTPSSLSLMHSPPGTQNISEINLSPMEISTFRIQLR
  
Inhibitor
Name:
BDBM84466
Synonyms:
Benzylation of mannostatin A, 1f
Type:
Small organic molecule
Emp. Form.:
C14H21NO4S
Mol. Mass.:
299.386
SMILES:
COc1ccc(CN[C@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]2SC)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: