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Target
Alpha-mannosidase 2
Ligand
BDBM50078117
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
36±0.0 nM
Citation
 Kuntz, DA; Zhong, W; Guo, J; Rose, DR; Boons, GJ The molecular basis of inhibition of Golgi alpha-mannosidase II by mannostatin A. Chembiochem 10:268-77 (2009) [PubMed]  Article 
Target
Name:
Alpha-mannosidase 2
Synonyms:
Alpha-mannosidase 2 | GmII | Golgi alpha-mannosidase II | MAN2_DROME | alpha-Man-IIa
Type:
Protein
Mol. Mass.:
126735.79
Organism:
Drosophila melanogaster (Fruit fly)
Description:
Q24451
Residue:
1108
Sequence:
MLRIRRRFALVICSGCLLVFLSLYIILNFAAPAATQIKPNYENIENKLHELENGLQEHGEEMRNLRARLAETSNRDDPIRPPLKVARSPRPGQCQDVVQDVPNVDVQMLELYDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGWIQTFEEYYQHDTKHILSNALRHLHDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQFMNVTPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYDIPHTCGPDPKVCCQFDFKRMGSFGLSCPWKVPPRTISDQNVAARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHINSQAHFNVQAQFGTLQEYFDAVHQAERAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHYVRAAEMLSAWHSWDGMARIEERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQEALKACQMVMQQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDILPSKHVVMHNTLPHWREQLVDFYVSSPFVSVTDLANNPVEAQVSPVWSWHHDTLTKTIHPQGSTTKYRIIFKARVPPMGLATYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPEDVKFGDPREISLRVGNGPTLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVRSHGDRSGAYLFLPNGPASPVELGQPVVLVTKGKLESSVSVGLPSVVHQTIMRGGAPEIRNLVDIGSLDNTEIVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPSGMFIEDANTRLTLLTGQPLGGSSLASGELEIMQDRRLASDDERGLGQGVLDNKPVLHIYRLVLEKVNNCVRPSELHPAGYLTSAAHKASQSLLDPLDKFIFAENEWIGAQGQFGGDHPSAREDLDVSVMRRLTKSSAKTQRVGYVLHRTNLMQCGTPEEHTQKLDVCHLLPNVARCERTTLTFLQNLEHLDGMVAPEVCPMETAAYVSSHSS
  
Inhibitor
Name:
BDBM50078117
Synonyms:
(1R,2R,3R,4S,5R)-4-AMINO-5-(METHYLTHIO)CYCLOPENTANE-1,2,3-TRIOL | (1R,2R,3R,4S,5R)-4-Amino-5-methylsulfanyl-cyclopentane-1,2,3-triol | CHEMBL9623 | Mannostatin A, 1 | Mannostatin A, 1a
Type:
Small organic molecule
Emp. Form.:
C6H13NO3S
Mol. Mass.:
179.237
SMILES:
CS[C@@H]1[C@@H](N)[C@@H](O)[C@@H](O)[C@H]1O
Structure:
Search PDB for entries with ligand similarity: