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Target
P2X purinoceptor 7
Ligand
BDBM274392
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
9.00±n/a nM
Citation
 Hilpert, K; Hubler, F; Renneberg, D; Stamm, S Indole carboxamide derivatives as P2X7 receptor antagonists US Patent  US9556117 Publication Date 1/31/2017 
Target
Name:
P2X purinoceptor 7
Synonyms:
ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor
Type:
Protein
Mol. Mass.:
68602.85
Organism:
Homo sapiens (Human)
Description:
Q99572
Residue:
595
Sequence:
MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
  
Inhibitor
Name:
BDBM274392
Synonyms:
US95556117, Example 56,4-Chloro-1H-indole-5-carboxylicacid [1-(2-hydroxy-ethanesulfonylamino)-cyclohexylmethyl]-amide
Type:
Small Organic Molecule
Emp. Form.:
C18H24ClN3O4S
Mol. Mass.:
413.919
SMILES:
OCCS(=O)(=O)NC1(CNC(=O)c2ccc3[nH]ccc3c2Cl)CCCCC1
Structure:
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