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Target
Hexokinase-4
Ligand
BDBM260383
Substrate
n/a
Meas. Tech.
ChEMBL_1664995 (CHEMBL4014791)
EC50
14±n/a nM
Citation
 Xu, J; Lin, S; Myers, RW; Trujillo, ME; Pachanski, MJ; Malkani, S; Chen, HS; Chen, Z; Campbell, B; Eiermann, GJ; Elowe, N; Farrer, BT; Feng, W; Fu, Q; Kats-Kagan, R; Kavana, M; McMasters, DR; Mitra, K; Tong, X; Xu, L; Zhang, F; Zhang, R; Addona, GH; Berger, JP; Zhang, B; Parmee, ER Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus. Bioorg Med Chem Lett 27:2063-2068 (2017) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM260383
Synonyms:
US9527838, 11
Type:
Small organic molecule
Emp. Form.:
C23H18N4O4S4
Mol. Mass.:
542.673
SMILES:
COc1ccc(Sc2ccc(Sc3ccccn3)nc2C(=O)Nc2ncc(SCC(O)=O)s2)cc1
Structure:
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