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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM50239765
Substrate
n/a
Meas. Tech.
ChEMBL_1666888 (CHEMBL4016684)
IC50
>20000±n/a nM
Citation
 Palomo, V; Perez, DI; Roca, C; Anderson, C; Rodríguez-Muela, N; Perez, C; Morales-Garcia, JA; Reyes, JA; Campillo, NE; Perez-Castillo, AM; Rubin, LL; Timchenko, L; Gil, C; Martinez, A Subtly Modulating Glycogen Synthase Kinase 3?: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases. J Med Chem 60:4983-5001 (2017) [PubMed]  Article 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM50239765
Synonyms:
CHEMBL1428911
Type:
Small organic molecule
Emp. Form.:
C20H27N3O4
Mol. Mass.:
373.4461
SMILES:
CCCCCCCC(=O)NNC(=O)c1c(O)c2ccccc2n(CC)c1=O
Structure:
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