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Target
Prolyl 4-hydroxylase subunit alpha-1
Ligand
BDBM50000864
Substrate
n/a
Meas. Tech.
ChEMBL_157457 (CHEMBL765597)
IC50
414000±n/a nM
Citation
 Cunliffe, CJ; Franklin, TJ; Hales, NJ; Hill, GB Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analogue N-oxaloglycine and its derivatives. J Med Chem 35:2652-8 (1992) [PubMed]  Article 
Target
Name:
Prolyl 4-hydroxylase subunit alpha-1
Synonyms:
P4HA1_RAT | P4ha | P4ha1 | Prolyl 4-hydroxylase alpha-1 subunit
Type:
PROTEIN
Mol. Mass.:
60891.28
Organism:
Rattus norvegicus
Description:
ChEMBL_157460
Residue:
534
Sequence:
MIWGVLMMGILLPQCSAHPGFFTSIGQMTDLIHNEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLILKDMSDGFISNLTIQRQYFPNDEDQVGAAKALFRLQDTYNLDTNTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALMQLEEGEMSTVDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLVYFEYIMSKEKDANKSASGDQSDQKTTPKKKGIAVDYLPERQKYEMLCRGEGIKMTPRRQKRLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATVHDPETGKLTTAQYRVSKSAWLSGYEDPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFRELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE
  
Inhibitor
Name:
BDBM50000864
Synonyms:
CHEMBL314175 | N-(2-Methanesulfonylamino-2-oxo-ethyl)-oxalamic acid
Type:
Small organic molecule
Emp. Form.:
C5H8N2O6S
Mol. Mass.:
224.192
SMILES:
CS(=O)(=O)NC(=O)CNC(=O)C(O)=O
Structure:
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